Initially manufactured by Bristol-Myers Squibb, Excedrin? over-the-counter pain reliever is now owned and produced by New Jersey-based Novartis Consumer Health, Inc.; the primary ingredients are acetaminophen, aspirin and caffeine. Introduced in the 1960s as the first multi-ingredient formulation headache treatment product, Excedrin? was one of the top ten selling over-the-counter medicine brands in the United States. First sold to relieve tension headaches; the brand today encompasses a variety of pain relief aids. Products include migraine pain reliever coated capsule caplets along with extra strength caplets designed to temporarily relieve minor aches and pains due to headache, cold, arthritis, muscular aches, toothache, as well as premenstrual and menstrual cramps. The migraine and extra strength pain and headache relief caplets are offered in packages of 24 and 100; the adult dosage is two caplets with a glass of water.